Welcome to PolyA_DB, a web resource for analysis of pre-mRNA cleavage and polyadenylation sites (polyA sites)


PolyA site databases

PolyA_DB 1


PolyA_DB version 1 contains human and mouse polyA sites mapped by cDNA/EST sequences.

Reference: Zhang H, Hu J, Recce M, Tian B. (2005). PolyA_DB: a database for mammalian mRNA polyadenylation. Nucleic Acids Res. 33:D116-20.

PolyA_DB 2


PolyA_DB version 2 contains polyA sites in human, mouse, rat, chicken and zebrafish that are mapped by cDNA/EST and Trace sequences. Sequence alignments between orthologous sites are also available.

Reference: Lee JY, Yeh I, Park JY, Tian B. (2007). PolyA_DB 2: mRNA polyadenylation sites in vertebrate genes. Nucleic Acids Res. 35:D165-8.

PolyA_DB 3


Many many polyA sites in many many species.

Coming soon...

PolyA site prediction and cis element analysis



PolyA_SVM predicts polyA sites using 15 cis elements identified for human polyA sites.

Reference: Cheng Y, Miura RM, Tian B. (2006). Prediction of mRNA polyadenylation sites by support vector machine. Bioinformatics 22:2320-5.

Please contact Bin Tian for questions/comments/suggestions.